Research Sheds Light on the Mystery Cause of Idiopathic Pulmonary Fibrosis

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New research could shed light on the mystery cause of a lung disease that is a major killer, and potentially unlock new treatments.

Idiopathic pulmonary fibrosis (IPF) affects at least 32,000 people in the UK, and accounts for one percent of all UK deaths, with patients having a life expectancy of three to five years once diagnosed. The disease involves scar tissue developing abnormally in the lungs, which progressively reduces the ability to breathe.

Up to now, the cause has been unknown - however, a new largescale research study led by the University of Exeter and published in The Lancet Respiratory Medicine has found that short telomeres - a protective component found on the ends of DNA - are linked to higher risk of having IPF.

Moreover, using a complex genetic analysis approach called Mendelian randomization, researchers found evidence that it's likely that the short telomeres cause IPF, as opposed to the disease itself causing telomere shortening.

The Exeter-based research team collaborated with the Royal Devon & Exeter NHS Foundation Trust, and the universities of Bath and Leicester, as well as patients affected by IPF. They examined data from 1,300 participants with IPF in UK Biobank and compared it with similar cohorts to ensure their results were replicated.

In healthy people, telomeres naturally get shorter as we age. But if this shortening is accelerated, it is thought to be one of the contributing factors to the health issues that we may encounter as we get older. Having less protection at the ends of our DNA can impair our bodies' ability to heal or fight off infection.

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