Initial and Subsequent DMT Choices in the Management of Multiple Sclerosis

Initial and Subsequent DMT Choices in the Management of Multiple Sclerosis

Initial and Subsequent DMT Choices in the Management of Multiple Sclerosis

How can clinicians tailor the treatment of multiple sclerosis to improve each patient’s personal and social quality of life? Join us to find out!

Available credits: 0.25

Time to complete: 15 minutes


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  • Overview

    Treatment goals for patients with multiple sclerosis continue to be refined as more and better disease-modifying drugs emerge from clinical trials and we accrue findings from real-world data. Nonetheless, the decision to match a patient with a particular drug agent has become more complex as we strive to achieve our treat-to-target goals and optimize patient outcomes.

    Drs. Coyle and Oh discuss how clinicians can best approach the medical management of patients with multiple sclerosis, both in the short and long term. The goal is to apply best clinical evidence while personalizing a patient’s therapy, thus offering the patient as normal a life as possible.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Commercial Support, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. GLC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Patricia K. Coyle, MD
    Director, MS Comprehensive Care Center
    Professor of Neurology
    Stony Brook University Medical Center
    Stony Brook, NY 

    Consulting Fees: Accordant, Biogen, Bristol Myers Squibb, Celgene, Genentech/Roche, Genzyme/Sanofi, GlaxoSmithKline, Janssen, Novartis, Viela Bio
    Contracted Research: Actelion, Alkermes, Corrona, LLC, Genentech/Roche, MedDay, NINDS, Novartis
    Commercial Interest Speakers Bureau: Biogen, Janssen 

    Jiwon Oh, MD
    Staff Neurologist
    St. Michael’s Hospital/University of Toronto
    Toronto, Ontario

    Consulting Fees: Biogen-Idec, EMD-Serono, Novartis, Roche, Sanofi
    Research Support: Biogen-Idec, Roche 

    Reviewers/Content Planners/Authors:

    • Ann Early has nothing to disclose.
    • Barry A. Fiedel, PhD, has nothing to disclose.
    • Amanda Hilferty has nothing to disclose.
    • Nick Lombardi has ownership interest in Vertex Pharmaceuticals.
    • Brian P. McDonough, MD, FAAFP, has nothing to disclose.
    • Colleen Resnick has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Apply best clinical evidence when personalizing therapy for patients with multiple sclerosis.
    • Identify patients who may benefit from switch strategies based on the failure to achieve NEDA.
    • Discuss multiple sclerosis-associated biomarkers that can assist in determining patient status and help direct patient management.
  • Target Audience

    This activity is designed to meet the educational needs of neurologists, primary care physicians, nurse practitioners, physician assistants, and registered nurses.

  • Accreditation and Credit Designation Statements

    Global Learning Collaborative is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

    Global Learning Collaborative designates this enduring material for a maximum of .25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider

    ReachMD Healthcare Image

    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties. 

    Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the very best education in the most impactful manner and to verify its results with progressive outcomes research. 

  • Commercial Support

    This activity is supported by independent educational grants from Biogen, Bristol Myers Squibb, and EMD Serono.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited

    Reproduction of this material is not permitted without written permission from the copyright owner.

  • System Requirements

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