Management of CRS and ICANS with CAR T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

Management of CRS and ICANS with CAR T-Cell Therapy for Relapsed/Refractory Multiple Myeloma

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Do you know how to manage CRS and ICANS occurring with CAR T-cell therapy? We’ve got the latest data on treatments and management of adverse events!

Available credits: 0.25

Time to complete: 15 minutes

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  • Overview

    CAR T-cell therapy offers the possibility of deep and durable remissions for patients with multiple myeloma who have relapsed after numerous lines of treatment. Learn about the most recent clinical data for the management of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS)—then put it into practice and improve outcomes for your patients.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Faculty:
    Caitlin Costello, MD
    Hematologist/Medical Oncologist
    Associate Professor of Medicine
    UC San Diego Health
    San Diego, CA

    Reviewers/Content Planners/Authors:

    • Stephen Chavez has nothing to disclose.
    • Cindy Davidson has nothing to disclose.
    • Amanda Hilferty has nothing to disclose.
    • Colleen Resnick has nothing to disclose.
    • Rosanne Strauss has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    • Discuss the current consensus grading systems for cytokine release syndrome (CRS) and immune effector cell-associated neurologic syndrome (ICANS) associated with CAR T-cell therapy
    • Describe the signs and symptoms of CRS and ICANS
    • Implement effective interdisciplinary team strategies to successfully manage CRS and ICANS in patients with relapsed/refractory multiple myeloma receiving CAR T-cell therapy
  • Target Audience

    This activity is designed to meet the educational needs of hematologists, oncologists, nurse practitioners, physician assistants, and nurses involved in the care and treatment of RRMM.

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    Global Learning Collaborative (GLC) designates this enduring activity for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for .25 nursing contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for .25 AAPA Category 1 CME credits. Approval is valid until April 28, 2024. PAs should claim only the credit commensurate with the extent of their participation in the activity. 

  • Provider(s)/Educational Partner(s)

    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties. 

    Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the very best education in the most impactful manner and to verify its results with progressive outcomes research.  

  • Commercial Support

    This activity is supported by an independent educational grant from Janssen. 

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

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