Weighing the Evidence: A Case-Based Review in Ulcerative Colitis

Weighing the Evidence: A Case-Based Review in Ulcerative Colitis

Weighing the Evidence: A Case-Based Review in Ulcerative Colitis
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There are new classes of therapies for ulcerative colitis. Are you selecting the most appropriate choice for your patients? Tune in to make sure!

Available credits: 0.25

Time to complete: 15 minutes

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  • Overview

    The proliferation of new classes of therapies for ulcerative colitis is affecting how we decide which treatments are most appropriate for our patients who are first- or second-line non-responders. This creates not only new challenges, but also new opportunities for all community gastroenterologists. Dr. Neil Nandi and Dr. David Rubin walk us through a case to highlight some of these challenges.  

    Since the completion of this activity, results from the ELEVATE UC 52 study, a yearlong phase 3 trial of etrasimod in moderate to severe ulcerative colitis, were announced. Etrasimod is an investigational, oral, once-a-day, selective sphingosine 1-phosphate (S1P) receptor modulator that showed positive 12- and 52-week results compared to placebo. Patients achieved statistically significant improvements in the co-primary endpoint of clinical remission at weeks 12 and 52 when compared to placebo. Statistically significant improvements were also attained in all key secondary endpoints at both 12 and 52 weeks. We will provide more data as the full results are published and presented in the future. 

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Host:
    Neilanjan Nandi MD, FACP
    Associate Professor of Clinical Medicine
    University of Pennsylvania
    Philadelphia, PA

    Consulting Fees: Pfizer IBD fellowship review committee

    Faculty:
    David T. Rubin
    Professor of Medicine
    University of Chicago Medicine
    Chicago, IL

    Consulting Fees: AbbVie, Alimentiv Inc., AltruBio, American College of Gastroenterology, Arena Pharmaceuticals, Aslan Pharmaceuticals, Athos Therapeutics, Bellatrix Pharmaceuticals, Boehringer Ingelheim Ltd, Bristol Myers Squibb, Celgene Corp/Syneos, ClostraBio, Connect BioPharma, Cornerstones Health Inc., EcoR1, Genentech/Roche, Gilead Sciences, Ironwood Pharmaceuticals, Iterative Scopes, Janssen Pharmaceuticals, Kaleido Biosciences, Eli Lilly & Co, Materia Prima, Pfizer, Prometheus Biosciences, Reistone Biopharma, Seres Therapeutics Inc., Takeda, Target RWE, Techlab Inc., Trellus Health
    Research: Takeda Other: AltruBio (Stock Agreement), American College of Gastroenterology (Board of Trustees), Cornerstones Health Inc. Non-profit (Co-founder, CFO)

    Reviewers/Content Planners/Authors:

    • Cindy Davidson has nothing to disclose.
    • Nick Lombardi no relevant relationships to report
    • William Mencia, MD, has nothing to disclose.
    • Collen Resnick has nothing to disclose.
    • Anna Trentini has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    1. Explain how recent advances in treatment are changing clinical practice for patients with ulcerative colitis (UC)
    2. Formulate strategies to select appropriate and individualized treatment plans for patients with moderate or severe UC
  • Target Audience

    This activity is designed to meet the educational needs of community gastroenterologists, GI nurse practitioners, and GI physician assistants.

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    Global Learning Collaborative (GLC) designates this enduring activity for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for 15 minutes of nursing contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider(s)/Educational Partner(s)

    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties.

    Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the very best education in the most impactful manner and to verify its results with progressive outcomes research.

  • Commercial Support

    This activity is supported by an independent educational grant from Takeda Pharmaceuticals USA, Inc.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

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