CWRU Researcher, Interdisciplinary Team Discover Breakthrough on Body’s Adaptation to COVID-19

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Peter Thomas

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Credit: Case Western Reserve University

CLEVELAND—Since 2020, the COVID-19 pandemic has presented significant challenges to global public health, infecting millions and claiming numerous lives. While widespread vaccination efforts have alleviated the immediate threat, lingering questions persist about the long-term effects of the virus on those infected.

An interdisciplinary team of scientists has made a significant breakthrough to understand how the body adapts to COVID-19 infection, potentially offering crucial insights into managing the complex disease. Led by  Christopher Wilson, professor of medicine at Loma Linda University, the collaborative effort involved researchers from Case Western Reserve University (CWRU) and the New Jersey Institute of Technology.

One puzzling phenomenon observed during the pandemic is the occurrence of “silent hypoxemia,” in which COVID-19 patients have dangerously low oxygen levels in their bloodstream without experiencing the typical symptoms of oxygen deprivation. This paradoxical effect, also known as "happy hypoxia," prompted researchers to investigate further.

By leveraging a mathematical model of breathing dynamics, developed in collaboration with Peter Thomas, professor of mathematics in CWRU’s College of Arts and Sciences, researchers simulated the conditions leading to silent hypoxemia.

Their findings, published in the journal Biological Cybernetics, suggest a potential link between elevated levels of hemoglobin in the bloodstream and the body's response to COVID-19 infection.

“I'm intrigued by the potential of this research to shed light on the enigmatic phenomenon of silent hypoxemia in COVID-19 patients,” Thomas said. “This research underscores the critical role of mathematical modeling in uncovering novel insights that could ultimately inform clinical practice and improve patient outcomes.”

The key research finding in the model was that one could produce sustained hypoxia without otherwise compromising breathing by increasing the parameter representing the hematocrit—the concentration of hemoglobin in the bloodstream. 

Hemoglobin is a special molecule that helps red blood cells carry oxygen from the lungs to the rest of the body. In communities living at high altitudes—such as the Tibetan Plateau or the Andes Mountains—many people have higher-than-average hemoglobin levels in their blood.  

Although COVID-19 can affect many parts of the body, it mainly attacks the respiratory system, making it difficult to breathe and causing blood clots in the lung. 

“In our research endeavors, we've unearthed a pivotal insight: the imperative for critical care physicians to vigilantly track hemoglobin levels in COVID-19 patients,” Thomas said. “This underscores the necessity to disseminate such crucial data within the research community—an action presently overlooked.”


Case Western Reserve University is one of the country's leading private research institutions. Located in Cleveland, we offer a unique combination of forward-thinking educational opportunities in an inspiring cultural setting. Our leading-edge faculty engage in teaching and research in a collaborative, hands-on environment. Our nationally recognized programs include arts and sciences, dental medicine, engineering, law, management, medicine, nursing and social work. About 6,200 undergraduate and 6,100 graduate students comprise our student body. Visit to see how Case Western Reserve thinks beyond the possible.


Biological Cybernetics

Method of Research

Data/statistical analysis

Subject of Research

Not applicable

Article Title

COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator

Article Publication Date


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