Evidence of Cerebral Microstructural Reorganization in Symptomatic Children Following Mild Traumatic Brain Injury

ReachMD Healthcare Image


New Rochelle, NY, November 16, 2023—A new study published in the peer-reviewed Journal of Neurotrauma shows that children with persistent symptoms following mild traumatic brain injury had evidence of ongoing cerebral microstructural changes. Click here to read the article now.

Athena Stein, from The University of Queensland, and coauthors, used brain MRI-based orientation dispersion index (ODI) metrics to study the microstructural damage in the brains of pediatric patients following “mild” TBI. The investigators studied children with persistent symptoms after injury and children displaying clinical recovery at 1 and 2-3 months post-TBI compared to healthy controls. Whole-brain ODI was significantly increased in symptomatic individuals compared to healthy controls at both 1- and 2-months post-injury. Symptomatic individuals had the highest ODI in all regions of interest. The ODI was lower in asymptomatic individuals, and healthy controls had the lowest ODI in all regions of interest. ODI progressively decreased over time alongside clinical recovery. 

“Our results show evidence of ongoing microstructural reorganization or neuroinflammation between 1- and 2-3 months post-injury, further supporting delayed return to play in children who remain symptomatic,” stated the investigators.

“This study is an important contribution to the field. In addition to revealing key insights into the pathophysiological correlates of symptomatic mild TBI in children, it identifies an objective imaging metric in this population which could be further developed as a clinical tool,” says James Stone, MD, PhD, Associate Editor of Journal of Neurotrauma.  

About the Journal
Journal of Neurotrauma is an authoritative peer-reviewed journal published 24 times per year in print and online that focuses on the latest advances in the clinical and laboratory investigation of traumatic brain and spinal cord injury. Emphasis is on the basic pathobiology of injury to the nervous system, and the papers and reviews evaluate preclinical and clinical trials targeted at improving the early management and long-term care and recovery of patients with traumatic brain injury. Journal of Neurotrauma is the official journal of the National Neurotrauma Society and the International Neurotrauma Society. Complete tables of content and a sample issue may be viewed on the Journal of Neurotrauma website

About the Publisher
Mary Ann Liebert, Inc. is a global media company dedicated to creating, curating, and delivering impactful peer-reviewed research and authoritative content services to advance the fields of biotechnology and the life sciences, specialized clinical medicine, public health and policy, and technology and engineering. For further information, please visit the Mary Ann Liebert, Inc. website.

Mary Ann Liebert, Inc.
140 Huguenot Street
New Rochelle, NY 10801
(914) 740-2100 or (800) M-LIEBERT
Fax (914) 740-2101

Facebook Comments


We’re glad to see you’re enjoying Prova Education…
but how about a more personalized experience?

Register for free