Human Platelet Extract and Vitamin C Show Comparable Efficacy for Treating Hand Photoaging

A new study published in Plastic and Reconstructive Surgery finds that topical treatments containing human platelet extract (HPE) and vitamin C provide similar improvements in reducing photoaging on the hands. The research suggests that both treatments are effective non-invasive options for managing age-related discoloration, or “age spots,” potentially offering an alternative to more invasive skin treatments.

Clinical Trial Compares Human Platelet Extract and Vitamin C for Hand Rejuvenation

Led by Dr. Saraya Wyles from the Mayo Clinic, the study included 60 middle-aged patients with moderate photoaging on the backs of their hands. Each participant followed a skincare routine that involved applying HPE to one hand and vitamin C to the other, twice daily, for 12 to 26 weeks. Assessments using digital imaging showed that both treatments significantly reduced brown spots, improved skin brightness, and enhanced color uniformity. By week 26, HPE showed about a 23% reduction in brown spot area, while vitamin C achieved around a 26% reduction, with outcomes appearing similar across both treatments.

Implications for Non-Invasive Skin Rejuvenation

These results suggest that HPE and vitamin C may offer simpler, less invasive approaches to rejuvenating the skin on the hands, comparable to results seen in laser-based photoaging treatments. Dr. Wyles noted the potential benefits of HPE over vitamin C, pointing out that while both products improve skin appearance, HPE may be a more user-friendly option due to its stability and lower tendency to cause photosensitivity.

Potential for Expanded Use in Skincare

The findings highlight the potential for including either HPE or vitamin C in routine skincare for photoaging, especially for patients interested in accessible hand rejuvenation options. Further studies could explore the possible benefits of using both treatments together or combining them with other therapies, potentially paving the way for new skincare regimens targeting photoaging across multiple body areas.