Targeting HER2 Across Advanced Solid Tumors

Biliary Tract and Pancreatic Cancer: HER2-Targeted ADCs for Gastrointestinal Cancers

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Overview
HER2-targeted treatments have been extensively researched and approved in breast, gastric, and non-small cell lung cancers. Are these same therapies effective at treating other HER2-positive tumors? Join our faculty as they examine the potential role for HER2-directed antibody-drug conjugates in treating advanced solid tumors and discuss the latest data around the efficacy and safety of these agents.
On April 5, 2024, the FDA granted accelerated approval to fam-trastuzumab deruxtecan-nxki (Enhertu, Daiichi Sankyo, Inc.) for adult patients with unresectable or metastatic HER2-positive (IHC3+) solid tumors who have received prior systemic treatment and have no satisfactory alternative treatment options. . To learn more about this approval, please visit: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-fam-trastuzumab-deruxtecan-nxki-unresectable-or-metastatic-her2
Disclosure of Relevant Financial Relationships
In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.
Faculty:
Susana Banerjee, MBBS, MA, FRCP, PhD
Consultant Medical Oncologist
Research Lead Gynaecology Unit
The Royal Marsden NHS Foundation Trust
Professor in Women’s Cancers
Dr. Banerjee has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months:
Consulting Fees: AstraZeneca, GlaxoSmithKline Immunogen, Merck Sharpe Dohme, Mersana, Myriad, Oncxerna, Seagen, Takeda, Verastem
Contracted Research: AstraZeneca,GlaxoSmithKline, Verastem, Immunogen, MSD, Mersana, Seagen
Ownership Interest: Phenutest
Bradley McGregor, MD
Director, Clinical Research for the Lank Center of Genitourinary Oncology
Dana-Farber Cancer Institute
Boston, MA
Dr. McGregor has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months:
Consulting Fees: BMS, Eisai, Exelixis, Gilead, Pfizer, Seagen
Contracted Research: BMS, Exelixis, Gilead, Pfizer, Seagen
Kathleen N. Moore, MD, MS
Co-Director, Cancer Therapeutics Program
Stephenson Cancer Center at the University of Oklahoma HSC
Oklahoma City, OK
Dr. Moore has reported the following relevant financial relationships or relationships with ineligible companies of any amount during the past 24 months:
Consulting Fees: Aadi, Aravive, Astra Zeneca, Blueprint, Clovis, Caris, Duality, Eisai, Genentech/Roche, GSK, Immunogen, Janssen, Lilly, Merck, Mersana, Onconova, Pannavance, Regeneron, VBL, Verastem, ZEntalis
Contracted Research: Aravie, Astra Zeneca, Blueprint, Clovis, Duality, GSK, Genentech/Roche, Immunogen, Lilly, PTC Therapeutics, Regeneron, Verastem
Shubham Pant, MD, MBBS
Associate Professor
Department of Gastrointestinal Medical Oncology
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX
Dr. Pant has reported no relevant disclosures at this time.
Reviewers/Content Planners/Authors:
Jorge Bacigalupo, PSM, has nothing to disclose.
Cindy Davidson has nothing to disclose.
Ann Early has nothing to disclose.
Amanda Hilferty has nothing to disclose.
Stephanie Wenick has nothing to disclose.
Learning Objectives
After participating in this educational activity, participants should be better able to:
- Evaluate the unmet need and rationale for exploring HER2 antibody-drug conjugates (ADCs) in advanced solid tumors.
- Analyze clinical trial evidence from ASCO and ESMO 2023 on HER2-directed ADCs in advanced solid tumors in the context of treatment sequencing.
- Identify the role of liquid biopsy in detecting HER2 alterations at baseline, during therapy, and/or at disease progression in advanced solid tumors.
Target Audience
This activity is designed to meet the educational needs of gynecologic oncologists, medical oncologists, community and academic practice ob-gyns, and GU specialists, urologists, and the advanced practice professionals associated with these specialties.
Accreditation and Credit Designation Statements
In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.
Global Learning Collaborative (GLC) designates this enduring activity for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Global Learning Collaborative (GLC) designates this activity for 1 nursing contact hour. Nurses should claim only the credit commensurate with the extent of their participation in the activity.
Provider(s)/Educational Partner(s)
Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties. 
Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the very best education in the most impactful manner and to verify its results with progressive outcomes research. 
Commercial Support
This activity is supported by an independent educational grant from AstraZeneca and Daiichi Sankyo, Inc.
Disclaimer
The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

Reproduction Prohibited
Reproduction of this materialis not permitted without written permission from the copyright owner.
System Requirements
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Publication Dates
Release Date: 01/17/2024
Expiration Date: 01/17/2025