Is Managing Gout in the Nephrology Clinic a Challenge?

The Underestimated Consequences of Uncontrolled Gout: Renal and Cardiovascular Implications

Is Managing Gout in the Nephrology Clinic a Challenge?

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  • Overview

    Conventional oral urate-lowering therapies frequently to fail to achieve target serum uric acid (sUA) levels in patients with chronic kidney disease and uncontrolled refractory gout. This can lead to increased urate burden and complications, including worsening kidney disease, cardiovascular events, and metabolic syndrome. Tune in to find out how to incorporate targeted therapies when managing uncontrolled refractory gout and improve your patients’ quality of life.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs. 

    Richard Johnson, MD
    Professor of Medicine
    University of Colorado
    Anschutz Medical Campus
    Aurora, CO

    Research: National Institute of Health
    Ownership Interest: Colorado Research Partners, XORTX Therapeutics
    Receives Royalties: Elsevier, BenBella Books
    Consulting Fees: Dinora, Horizon Pharma
    Other: RxSugar

    Abdul A. Abdellatif, MD, FASN
    Division of Nephrology
    Baylor College of Medicine and CLS Health
    Houston, TX

    No relevant relationships reported

    John K. Botson, MD, RPh
    Director of Rheumatology
    Orthopedic Physicians Alaska
    Anchorage, AK

    Research: Horizon Therapeutics
    Patent Holder: Horizon Therapeutics
    Consulting Fee: AbbVie, Amgen, Eli Lilly, Horizon Therapeutics, Novartis

    Brittany Weber, MD, PhD
    Director, Cardio-Rheumatology Clinic
    Associate Physician, Prevention Cardiology & Cardiovascular Imaging
    Brigham and Women’s Hospital
    Boston, MA

    Research: AHA, NIH
    Consulting Fees:, Agepha, Horizon Therapeutics, Kiniksa, Novo Nordisk

    Reviewers/Content Planners/Authors:

    • Cindy Davidson has nothing to disclose.
    • Hany Ibrahim, MD, has nothing to disclose.
    • Samantha Keehn has nothing to disclose.
    • John Maeglin has nothing to disclose.
    • Brian McDonough has nothing to disclose.
    • Tim Person has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:  

    • Discuss the pathophysiology and prevalence of high uric acid levels and uncontrolled gout in patients with renal disease and the contribution of chronic gout to chronic kidney disease (CKD) progression, associated comorbidities, and increased mortality
    • Apply knowledge of available diagnostic tools to identify patients with elevated serum uric acid (sUA) levels early in the progression of CKD to initiate proper urate-lowering therapy (ULT) and reduce urate burden
    • Summarize the limitations of standard ULT options in patients with CKD 
    • Incorporate emerging urate-lowering therapies, including pegloticase-methotrexate combined therapy and clinical trial evidence, into clinical practice in the treatment of appropriate patients with uncontrolled gout 
    • Discuss gout as an independent risk factor for CVD and its association with CVD morbidity and mortality, necessitating early screening and treatment to attain target sUA levels 
  • Target Audience

    This activity is designed to meet the educational needs of nephrologists, rheumatologists, cardiologists, primary care physicians, and others who encounter, diagnose, and treat gout.

  • Accreditation and Credit Designation Statements

     In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team. 

    Global Learning Collaborative (GLC) designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for 1.0 nursing contact hour. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider(s)/Educational Partner(s)

    Prova Education designs and executes continuing education founded on evidence-based medicine, clinical need, gap analysis, learner feedback, and more. Our mission is to serve as an inventive and relevant resource for clinical content and educational interventions across a broad spectrum of specialties.
    Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the very best education in the most impactful manner and to verify its results with progressive outcomes research. 

  • Commercial Support

    This activity is supported by an independent educational grant from Horizon Therapeutics, USA, Inc.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to access a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

  • System Requirements

    • Supported Browsers (2 most recent versions):
      • Google Chrome for Windows, Mac OS, iOS, and Android
      • Apple Safari for Mac OS and iOS
      • Mozilla Firefox for Windows, Mac OS, iOS, and Android
      • Microsoft Edge for Windows
    • Recommended Internet Speed: 5Mbps+

  • Publication Dates

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